How an Early Female Travel Writer Became an Immunization Pioneer

Lady Mary Wortley Montagu by A. Devéria
Lady Mary Wortley Montagu by A. Devéria

Lady Mary Wortley Montagu was a British aristocrat, feminist, and writer who was famed for her letters. If that were all she did, she would be a slightly obscure example of a travel writer and early feminist. But she was also an important public health advocate who is largely responsible for the adoption of inoculation against smallpox—one of the earliest forms of immunization—in England.

Smallpox was a scourge right up until the mid-20th century. Caused by two strains of Variola virus, the disease had a mortality rate of up to 35 percent. If you lived, you were left with unsightly scars, and possible complications such as severe arthritis and blindness.

Lady Montagu knew smallpox well: Her brother died of it at the age of 20, and in late 1715, she contracted the disease herself. She survived, but her looks did not; she lost her eyelashes and was left with deeply pitted skin on her face.

When Lady Montagu’s husband, Edward Wortley Montagu, was appointed ambassador to Turkey the year after her illness, she accompanied him and took up residence in Constantinople (now Istanbul). The lively letters she wrote home described the world of the Middle East to her English friends and served for many as an introduction to Muslim society.

One of the many things Lady Montagu wrote home about was the practice of variolation, a type of inoculation practiced in Asia and Africa likely starting around the 15th or 16th century. In variolation, a small bit of a pustule from someone with a mild case of smallpox is placed into one or more cuts on someone who has not had the disease. A week or so later, the person comes down with a mild case of smallpox and is immune to the disease ever after.

Lady Montagu described the process in a 1717 letter:

"There is a set of old women, who make it their business to perform the operation, every autumn, in the month of September, when the great heat is abated. People send to one another to know if any of their family has a mind to have the small-pox: they make parties for this purpose, and when they are met (commonly fifteen or sixteen together) the old woman comes with a nuts-hell full of the matter of the best sort of small-pox, and asks what veins you please to have opened. She immediately rips open that you offer to her with a large needle (which gives you no more pain than a common scratch), and puts into the vein as much matter as can lye upon the head of her needle, and after that binds up the little wound with a hollow bit of shell; and in this manner opens four or five veins. . . . The children or young patients play together all the rest of the day, and are in perfect health to the eighth. Then the fever begins to seize them, and they keep their beds two days, very seldom three. They have very rarely above twenty or thirty in their faces, which never mark; and in eight days' time they are as well as before their illness."

So impressed was Lady Montagu by the effectiveness of variolation that she had a Scottish doctor who worked at the embassy, Charles Maitland, variolate her 5-year-old son in 1718 with the help of a local woman. She returned to England later that same year. In 1721, a smallpox epidemic hit London, and Montagu had Maitland (who by then had also returned to England) variolate her 4-year-old daughter in the presence of several prominent doctors. Maitland later ran an early version of a clinical trial of the procedure on six condemned inmates in Newgate Prison, who were promised their freedom if they took part in the experiment. All six lived, and those later exposed to smallpox were immune. Maitland then repeated the experiment on a group of orphaned children with the same results.

A painting of Lady Mary Wortley Montagu with her son, Edward Wortley Montagu, and attendants
Lady Mary Wortley Montagu with her son, Edward Wortley Montagu, and attendants
Jean-Baptiste Vanmour, Art UK // CC BY-NC-ND

But the idea of purposely giving someone a disease was not an easy sell, especially since about 2 or 3 percent of people who were variolated still died of smallpox (either because the procedure didn’t work, or because they caught a different strain than the one they had been variolated with). In addition, variolated people could also spread the disease while they were infectious. Lady Montagu also faced criticism because the procedure was seen as “Oriental,” and because of her gender.

But from the start, Lady Montagu knew that getting variolation accepted would be an uphill battle. In the same letter as her first description of the practice, she wrote:

"I am patriot enough to take pains to bring this useful invention into fashion in England; and I should not fail to write to some of our doctors very particularly about it, if I knew any one of them that I thought had virtue enough to destroy such a considerable branch of their revenue for the good of mankind. But that distemper is too beneficial to them, not to expose to all their resentment the hardy wight that should undertake to put an end to it. Perhaps, if I live to return, I may, however, have courage to war with them."

As promised, Lady Montagu promoted variolation enthusiastically, encouraging the parents in her circle, visiting convalescing patients, and publishing an account of the practice in a London newspaper. Through her influence, many people, including members of the royal family, were inoculated against smallpox, starting with two daughters of the Princess of Wales in 1722. Without her advocacy, scholars say, variolation might never have caught on and smallpox would have been an even greater menace than it was. The famed poet Alexander Pope said that for her, immortality would be "a due reward" for "an action which all posterity may feel the advantage of," namely the "world’s being freed from the future terrors of the small-pox."

Variolation was performed in England for another 70 years, until Edward Jenner introduced vaccination using cowpox in 1796. Vaccination was instrumental in finally stopping smallpox: In 1980, it became the first (and so far, only) human disease to be completely eradicated worldwide.

5 Fast Facts About Billy the Kid

On September 23, 1875, Billy the Kid was arrested for the first time. Whether you think he was a misunderstood old West hero or nothing but a cold-blooded killer, it's impossible to argue that he was an interesting man. Here are five facts to prove it.

1. HIS "REAL" NAME IS A TOPIC OF DEBATE.

Billy the Kid's real name? Henry McCarty. Or maybe William Bonney. Or Henry Antrim. Take your pick. He was born Henry McCarty, but there's some speculation that his dad may have been a man named William Bonney. Billy the Kid started using his name at some point in 1877. Antrim was his step-father's last name; he went by that for some time as well.

2. HE WORKED AT A CHEESE FACTORY.

Billy the Kid wasn't always engaging in illegal activities and shooting people; he once worked at a cheese factory—at least he did according to Charlie Bowdre, a man who would later be in Billy's posse, and was part owner of the cheese factory. Bowdre's descendants have said this is where the two of them met, although his employ was short.

3. HIS LEGEND MAY BE A BIT OF AN EXAGGERATION.

You may have heard the legend that Billy killed 21 people—one for each year of his rather short life. It's just that: legend. We only have evidence that Billy killed four people, two of them prison guards. He may have "participated" in the deaths of up to five more people.

4. CONTRARY TO POPULAR BELIEF, HE PROBABLY WASN'T LEFT-HANDED.

The reason this notion became widespread is because of the famous ferrotype of him that shows him wearing a gun belt with the holster on the left side. It was later discovered that the image has been reproduced incorrectly and flipped to show the mirror image of what really was. The picture actually shows Billy with his gun on his right hip.

5. SOME PEOPLE BELIEVE HE FAKED HIS OWN DEATH.

Many people—including some claiming to be Billy himself—have said Billy didn't actually die on July 14, 1881 in Fort Sumner, New Mexico, which is the official story. Many claim that Sheriff Pat Garrett didn't kill Billy, but actually helped him fake his death and happily ride off into the sunset. No evidence has ever been found to support this, though.

Men claiming to be Billy include Ollie "Brushy Bill" Roberts and a man named John Miller. Brushy Bill started claiming to be Billy the Kid in 1949, and knew quite a few intimate details about Billy's life and the Lincoln Country War. But there were several gunfights he was pretty clueless about, and photo comparisons using sophisticated computer programs show the men to have completely different bone structure and other features.

As for John Miller, his claims were basically put to rest in 2005 when his bones were disinterred and DNA samples were taken. They were compared to a blood sample thought to be Billy the Kid's and there was no match.

10 Electrifying Facts About Michael Faraday

iStock
iStock

This world-changing genius was born into poverty on September 22, 1791. Fortunately for us, Michael Faraday refused to let his background stand in his way.

1. HE WAS LARGELY SELF-EDUCATED.

In Faraday's boyhood home, money was always tight. His father, James, was a sickly blacksmith who struggled to support a wife and four children in one of London's poorer outskirts. At age 13, young Faraday started helping the family make ends meet. Bookseller George Ribeau (sometimes spelled Riebau) took him on as an errand boy in 1804, with the teen's primary job being the delivery and recovery of loaned-out newspapers.

Shortly after Faraday's 14th birthday, Ribeau offered him a free apprenticeship. Over the next seven years, he mastered the trade of bookbinding. After hours, Faraday remained in Ribeau's store, hungrily reading many of the same volumes he'd bound together.

Like most lower-class boys, Faraday's formal schooling was very limited. Between those bookshelves, however, he taught himself a great deal—especially about chemistry, physics, and a mysterious force called "electricity."

2. A 300-PAGE NOTEBOOK LAUNCHED HIS SCIENTIFIC CAREER.


Wikimedia Commons // CC BY 4.0 

Sir Humphry Davy (above) left a huge mark on science. In the year 1808 alone, the man discovered no less than five elements, including calcium and boron. An excellent public speaker, Davy's lectures at the Royal Institution consistently drew huge crowds. 

Twenty-year-old Faraday attended four of these presentations in 1812, having received tickets from a customer. As Davy spoke, Faraday jotted down detailed notes, which he then compiled and bound into a little book. Faraday sent his 300-page transcript to Davy. Duly impressed, the seasoned scientist eventually hired him as a lab assistant. Later in life, Davy was asked to name the greatest discovery he'd ever made. His answer: "Michael Faraday."

Tension would nevertheless erupt between mentor and protégé. As Faraday's accomplishments began to eclipse his own, Davy accused the younger man of plagiarizing another scientist's work (this rumor was swiftly discredited) and tried to block his admission to the Royal Society.

3. IF IT WEREN'T FOR FARADAY, WE MIGHT NOT HAVE ELECTRIC POWER.

On September 3, 1821, Faraday built a device that ushered technology into the modern era. One year earlier, Danish physicist Hans Christian Ørsted had demonstrated that when an electric current flows through a wire, a magnetic field is created around it. Faraday capitalized on this revelation. Inside the Royal Society basement, he began what was arguably his most groundbreaking experiment by placing a magnet in the bottom of a mercury-filled glass container. Dangling overhead was a wire, which Faraday connected to a battery. Once an electric current was conducted through the wire, it began rotating around the magnet.

Faraday had just built the world's first electric motor. How could he possibly top himself? By building the world's first electric generator. His first experiment was comprised of a simple ring of wires and cotton through which he passed a magnet. By doing so, he found that a current was generated. To this day, most electricity is made using the same principles.

4. FARADAY INVENTED THE RUBBER BALLOON.


iStock

By today's standards, his early models would look shabby. Made via pressing two sheets of rubber together, Faraday's balloons were used to contain hydrogen during his experiments. Faraday created his first in 1824 and was quick to praise the bag's “considerable ascending power.” Toy manufacturers started distributing these the following year.

5. HE'S ALSO THE GRANDFATHER OF MODERN REFRIGERATORS.

In 1823, Faraday sealed a sample of chlorine hydrate inside a V-shaped tube. As he heated one end and cooled the other simultaneously, the scientist noticed that a peculiar yellow liquid was starting to form. Curious, he broke open the tube. Without warning, a sudden, violent explosion sent glass shards flying everywhere. Mercifully uninjured, he smelled a strong scent of chlorine in the air.

It didn't take him very long to figure out what had happened. Inside the tube, pressure was building, which liquefied the gas. Upon puncturing the glass, he'd released this pressure and, afterwards, the liquid reverted into its gaseous state. This sudden evaporation came with an interesting side-effect: it cooled down the surrounding air. Quite unintentionally, Faraday thus set the stage for the very first ice-making machines and refrigeration units.

6. HE BECAME AN ANTI-POLLUTION CRUSADER.

Britain's industrialization came at a malodorous price. As London grew more crowded during the mid-1800s, garbage and fecal matter were dumped into the River Thames with increasing regularity. Naturally, the area didn't smell like a rose. In 1855, Faraday penned an oft-reproduced open letter about the problem, imploring the authorities to take action. “If we neglect this subject,” he wrote, “we cannot expect to do so with impunity; nor ought we be surprised if, ere many years are over, a hot season give us sad proof for the folly of our carelessness.”

Just as Faraday predicted, a broiling summer forced Londoners of all stripes to hold their noses. Dubbed “the Great Stink,” the warmer months of 1858 sent the Thames' rancid odor wafting all over the city. Parliament hastily responded with a comprehensive sewage reform bill. Gradually, the putrid stench began to dissipate.

7. HE STARTED THE ROYAL SOCIETY'S CHRISTMAS LECTURE TRADITION.


Alexander Blaikley, Wikimedia Commons, Public Domain

Faraday understood the importance of making science accessible to the public. In 1825, while employed by the Royal Society, he spearheaded an annual series that's still going strong today. That holiday season, engineer John Millington delivered a set of layman-friendly lectures on “natural philosophy.” Every year thereafter (excluding 1939–1942 because of WWII), a prominent scientist has been invited to follow in his footsteps. Well-known Christmas lecturers include David Attenborough (1973), Carl Sagan (1977), and Richard Dawkins (1991). Faraday himself was the presenter on no less than 19 occasions.

8. BRILLIANT AS FARADAY WAS, HE STRUGGLED WITH MATH.

Towards the end of his life, Faraday's lack of formal education finally caught up with him. An underprivileged childhood had rendered him mathematically illiterate, a severe handicap for a professional scientist. In 1846, he hypothesized that light itself is an electromagnetic phenomenon, but because Faraday couldn't support the notion with mathematics, it wasn't taken seriously. Salvation for him came in the form of a young physicist named James Clerk Maxwell. Familial wealth had enabled Maxwell to pursue math and—in 1864—he released equations [PDF] that helped prove Faraday's hunch.

9. AS TIME WORE ON, HE STRUGGLED WITH MEMORY LOSS.

Michael Faraday
iStock

At the age of 48, Faraday's once-sharp memory started faltering. Stricken by an illness that rendered him unable to work for three years, he wrestled with vertigo, unsteadiness, and other symptoms. Following this "extended vacation" [PDF], he returned to the Royal Society, where he experimented away until his early 70s.

However, Faraday was still prone to inexplicable spurts of sudden giddiness, depression, and extreme forgetfulness. “[My] bad memory,” he wrote, “both loses recent things and sometimes suggests old ones as new.” Nobody knows what caused this affliction, though some blame it on overexposure to mercury.

10. EINSTEIN KEPT A PORTRAIT OF FARADAY IN HIS BERLIN HOME.

Fittingly, the father of modern physics regarded Faraday as a personal hero. Once, upon receiving a book about him, Einstein remarked, “This man loved mysterious Nature as a lover loves his distant beloved.”

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